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Structure of Akt1 in active and inhibitor bound forms. (A) Structure of ΔPH-pAkt1Thr308 Ser473Asp (PDB 1O6K [35]) is shown in complex with ATP analog (ANP-PNP) and substrate peptide (purple). (B) Structure of the full-length Akt1 (unphosphorylated) is shown in complex with the Akti-1/2 inhibitor VIII (PDB 1O96 [36]) binding in the cleft between the kinase domain (green) and the N-terminal PH domain (red).
