Table 3.
Genotype and allelic frequencies of rs2043556 and rs4541843 according the number of BC cases in the families in BRCA1/2-negative breast cancer cases and controls.
| Families with 2 BC and/or OC Cases (n = 148) | Families with ≥3 BC and/or OC Cases (n = 121) | ||||||
|---|---|---|---|---|---|---|---|
| Genotype or Allele | Controls (n = 1048) (%) | BC Cases (%) | p-Value a | OR [95% CI] | BC Cases (%) | p-Value a | OR [95% CI] |
| rs2043556 (miR-605) | |||||||
| T/T | 376 (35.9) | 67 (45.3) | - | 1.0 (Ref) | 61 (50.4) | - | 1.0 (Ref) |
| T/C | 571 (54.5) | 68 (45.9) | 0.08 | 0.7 [0.5–1.0] | 47 (38.9) | 0.003 | 0.5 [0.4–0.8] |
| C/C | 101 (9.6) | 13 (8.8) | 0.3 | 0.7 [0.4–1.4] | 13 (10.7) | 0.5 | 0.7 [0.4–1.5] |
| T/C + C/C | 672 (64.1) | 81 (54.7) | 0.06 | 0.7 [0.5–1.0] | 60 (49.6) | 0.006 | 0.5 [0.4–0.9] |
| Allele T | 1323 (63.1) | 202 (68.2) | - | 1.0 (Ref) | 169 (69.8) | - | 1.0 (Ref) |
| Allele C | 773 (36.9) | 94 (31.8) | 0.1 | 0.8 [0.6–1.0] | 73 (30.2) | 0.06 | 0.7 [0.5–1.0] |
| rs4541843 (Pri-miR-182) | |||||||
| C/C | 386 (36.8) | 45 (30.4) | - | 1.0 (Ref) | 36 (29.8) | - | 1.0 (Ref) |
| C/T | 473 (45.1) | 70 (47.3) | 0.2 | 1.2 [0.8–1.8] | 57 (47.1) | 0.2 | 1.2 [0.8–1.9] |
| T/T | 189 (18.1) | 33 (22.3) | 0.1 | 1.4 [0.8–2.4] | 28 (23.1) | 0.09 | 1.5 [0.9–2.6] |
| C/T + T/T | 662 (63.2) | 103 (69.6) | 0.1 | 1.3 [0.9–1.9] | 85 (70.2) | 0.1 | 1.3 [0.9–2.0] |
| Allele C | 1245 (59.4) | 160 (54.1) | - | 1.0 (Ref) | 129 (53.3) | - | 1.0 (Ref) |
| Allele T | 851 (40.6) | 136 (45.9) | 0.09 | 1.2 [0.9–1.5] | 113 (46.7) | 0.07 | 1.2 [0.9–1.6] |
BC—breast cancer; OC—ovarian cancer; OR—odds ratio; CI—confidence interval; Ref—Reference. a Fisher’s exact test. p < 0.05 Statistically significant.