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. 2018 Sep 5;9(9):443. doi: 10.3390/genes9090443

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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DE lncRNAs revealed the changes in the lung after birth. (A) DE lncRNAs with q value ≤ 0.05: 312 were down-regulated, 140 were up-regulated; (B) DE lncRNAs distribution based on the ratio of DE genes per highly-related genes and the total highly-related mRNA number. Highly related genes were identified by comparison between mRNAs and lncRNAs as described in methods. A total of 136 lncRNAs had more than 200 related genes and only 10 lncRNAs (marked in red) with a ratio (DE genes per highly-related genes) ≥0.35; (C) Functional enrichment analysis of the top ten lncRNAs in (B) with their related genes, the highly related DE genes were used as gene list while the highly related genes were set as background. Categories (p value < 0.05) related to cell proliferation and immune response were listed.