Table 1.
Novel anticancer bioactive compounds reported from mangrove fungi.
| Sr. No. | Fungus | Host Plant(s) | Plant Part or Tissue Locality of Host Plants | Compounds Isolated | Cell Line | IC50/EC50/Inhibition | Refs. |
|---|---|---|---|---|---|---|---|
| Compounds Produced by Coelomycetes | |||||||
| 1 | Pestalotiopsis sp. | Rhizophora mucronata | Not reported | Demethylincisterol A3 (1) | HeLa, A549 and HepG | In the range of 0.17 to 14.16 nM | [16] |
| Ergosta-5,7,22-trien-3-ol (2), stigmastan-3-one (3), stigmast-4-en-3-one (4), stigmast4-en-6-ol-3-one (5), flufuran (6) | HeLa, A549 and HepG | In the range of 11.44–102.11 µM | |||||
| 2 | Pestalotiopsis microspore | Drepanocarpus lunatus | Cameroon | Compound (7) Pestalotioprolide D–F (8–10) | L5178Y | 0.7, 5.6, 3.4, and 3.9 µM | [17] |
| Pestalotioprolide E (9) | A2780 | 1.2 µM | |||||
| 3 | Pestalotiopsis clavispora | Rhizophora harrisonii | Port Harcourt, Nigeria | Pestalpolyol I (11) | L5178Y | 4.10 µM | [18] |
| 4 | Pestalotiopsis vaccinia | Kandelia candel | China | Pestalamine A (12) | MCF-7, HeLa, and HepG2 | 40.3, 22.0, and 32.8 µM | [19] |
| 5 | Phoma sp. OUCMDZ-1847 | Fruit sample of Kandelia candel | Wenchang, Hainan Province, China | Phomazines B (13), epicorazine A (14), epicorazine B (15), epicorazine C (16), exserohilone A (17) | HL-60, HCT-116, K562, MGC-803, and A549 Cells | In the range 0.05 to 8.5 µM | [20] |
| 6 | Phomopsis sp. | Zhanjiang, China | Cytochalasin H (18) | A549 cells | Arrested A549 cells at the G2/M phase, inhibited the migration ability of A549 cells in a dose-dependent manner | [21] | |
| 7 | Phomopsis spp. xy21 and xy22 | Leaves Xylocarpus granatum | Trang Province, Thailand | Phomopsichalasin G (19) | HCT-8, HCT-8/T, A549, MDA-MB-231, and A2780 cancer Cells | 7.5, 8.6, 6.4, 3.4, and 7.1 µM | [22] |
| 8 | Phomopsis longicolla HL-2232 | Bruguiera sexangula var. rhynchopetala | 6-aminopurine-9-carboxylic acid Me ester (20), uridine (21) | B16F10, A549, HL-60 and MCF-7 Cells | 14.9 and 8.6 µM | [23] | |
| 9 | Phomopsis sp. HNY29-2B | Branch of Acanthus llicifolius | South China Sea, Hainan province, China | Dicerandrol A (22) | MDA-MB-435, HCT-116, Calu-3 and Huh7 Cells | 3.03, 2.64, 1.76 and 4.19 µM | [24] |
| Dicerandrol B (23), Penexanthone A (26) | MDA-MB-435, HCT-116 and Calu-3 | <10 µM | |||||
| Dicerandrol C (24) | MDA-MB-435, HCT-116, Calu-3, MCF-10A Cells | 44.10, 42.63, 36.52, and 33.05 µM | |||||
| diacetyl phomoxanthone B (25) | MDA-MB-435, HCT-116, Calu-3, Huh7 Cells | 14.40, 7.12, 4.14 and 29.20 µM | |||||
| 10 | Phomopsis sp. (ZH76) | Excoecaria agallocha | Dong Sai, South China Sea coast | 3-O-(6-O-α-l-arabinopyranosyl)-β-d-glucopyranosyl-1,4-dimethoxyxanthone (27) | HEp-2 and HepG2 | 9 and 16 µM | [25] |
| 11 | Diaporthe sp. SCSIO 41011 | Rhizophora stylosa | Sanya city, Hainan Province, China | Isochromophilone D (28) | 786-O cells | 8.9 µM | [26] |
| epi-Isochromophilone II (29) | ACHN, OS-RC-2, and 786-O cells, | In the range of 3.0 to 4.4 µM, Sorafenib (3.4 to 7.0 µM) | |||||
| 12 | Diaporthe phaseolorum SKS019 | Branches of Acanthus ilicifolius | Shankou, Guangxi province, China | 5-deoxybostrycoidin (30) | MDA-MB-435 and NCI-H460 cancer cells | 5.32 and 6.57 µM | [27] |
| Fusaristatin A (31) | MDA-MB-435 cancer cells | 8.15 µM | |||||
| 13 | Phomosis sp. A818 | Foliage of Kandelia candel | Fujian Province, China | Mycoepoxydiene (32), deacetylmycoepoxydiene (33) | MDA-MB-435 | 7.85 and 14.61 µM, | [28] |
| 14 | Phomosis sp. A818 | Foliage of Kandelia candel | Fujian Province, China | Mycoepoxydiene (32) | Suppress antigen-stimulated degranulation and cytokine production in mast cells and IgE-mediated passive cutaneous anaphylaxis in mice | [29] | |
| Compounds Produced by Ascomycetes | |||||||
| 15 | Sarocladium kiliense HDN11-84 | rhizosphere soil of Thespesia populnea, | Guangxi Province, China | Saroclazine B (34) | HeLa Cells | 4.2 µM | [30] |
| 16 | Annulohypoxylon sp. | Rhizophora racemosa | Cameroon | Daldinone I (35) | Ramos and Jurkat J16 | 6.6 and 14.1 µM, Potently blocks autophagy, a potential pro-survival pathway for cancer cells | [31] |
| 17 | Eurotium rubrum | Suaeda salsa | “BoHai” seaside, China | Rubrumol (36) | A549, MDA-MB-231, PANC-1 and HepG2 | Cytotoxic | [32] |
| Topo I | Relaxation activity The band backward shifting and trailing of rubrumol (36) was observed at 100, 50, 10, 5 and 1 µM | ||||||
| 18 | Eutypella sp. 1–15 | Soil of mangrove rhizosphere in Jimei, Fujian Province, China | Not reported | 13-Hydroxy-3,8,7(11)-eudesmatrien-12,8-olide (37) | JEKO-1 and HepG2 | 8.4 and 28.5 µM | [33] |
| 19 | Rhytidhysteron rufulum AS21B | Leaves of Azima sarmentosa | Samutsakhon province, Thailand | Rhytidenones G (38), H (39)), deoxypreussomerin B (40), palmarumycin CP17 (41), 1-oxo-1,4-dihydronapthalene-4-spiro-20-naptho[400-hydroxy-100,800-de][10,30]-dioxine (42), preussomerin EG4 (43), rhytidenone E (44), rhytidenone F (45), palmarumycin C5 (46), and 4,8-dihydroxy-3,4-dihydronaphthalen-1(2H)-one (47) | Ramos lymphoma | 17.98, 0.018, 18.00, 33.1, 15, 82.9, 0.461, 0.048, 31.7 and 23.1 µM, (Ibrutinib 28.7 µM) | [34] |
| Compounds (38), (39), (44), (45), and (47) | H1975 Cell | 7.3, 0.252, 10.24, 1.17 and 50 µM (afatinib 1.97 µM) | |||||
| 20 | Lasiodiplodia sp. 318# | Excoecaria agallocha | Guangdong Province, China | 2,4-Dihydroxy-6-nonylbenzoate (48) | MMQ and GH3 Cells | 5.2 and 13.0 µM | [35] |
| 21 | Lasiodiplodia sp. 318# | Excoecaria agallocha | Guangdong Province, China | Ethyl-2,4-dihydroxy-6-(80-hydroxynonyl)-benzoate (49) | MDA-MB-435, HepG2, HCT-116, A549 and leukaemia THP1 Cells | 0.13, 12.50, 11.92, 13.31 and 39.74 µM | [36] |
| 22 | Lasiodiplodia theobromae ZJ-HQ1 | Acanthus ilicifolius | Guangdong Province, China | Chloropreussomerins A and B (50, 51) Preussomerin D (56) | A549 and MCF-7 | In the range of 5.9–8.9 µM | [37] |
| Preussomerin K (52), Preussomerin H (53), Preussomerin G (54), Preussomerin F (55), | A549, HepG2, MCF-7 | In the range of 2.5–9.4 µM | |||||
| 23 | Rhytidhysteron rufulum BG2-Y | Leaves of Bruguiera gymnorrhiza | Pak Nam Pran, Prachuab Kiri Khan Province, Thailand | Rhytidchromone A (57), B (58), C (59), and E (60) | Kato-3 Cells | In the range of 16.0–23.3 µM | [38] |
| MCF-7 cells | 19.3–17.7 µM | ||||||
| 24 | Campylocarpon sp. HDN13-307 | Root of Sonneratia caseolaris | China | Campyridone D (61), and ilicicolin H (62) | HeLa | 8.8 and 4.7 µM | [39] |
| 25 | Stemphylium globuliferum | Avicennia marina | Hurghada, Egypt | Dihydroaltersolanol C (63), Altersolanol A (64), Altersolanol B (65), Alterporriol E (67) | L5178Y | 3.4, 2.53, 3.78 and 6.9 µM | [40,41,42] |
| Altersolanol N (66) | L5178Y | Low micromolar range (% growth-1.4) | |||||
| 26 | Paradictyoarthrinium diffractum BCC 8704 | Associated with mangrove wood | Laem SonNational Park, Ranong Province, Thailand | Paradictyoarthrins A (68) | KB, MCF-7, NCI-H187, Vero Cells, KB, MCF-7, NCI-H187, Vero Cells | In the range of 23–31 µg/mL | [46] |
| Paradictyoarthrin B (69) | KB, MCF-7, NCI-H187, Vero Cells | 3.1, 3.8, 9.5, and 5.6 µg/mL | |||||
| Preussomerin C (70), ymf 1029C (71) and altenusin (72) | KB, MCF-7, NCI-H187, Vero Cells | Moderate to poor activity | |||||
| ymf 1029C (71) | NCI-H187 cells | 5.0 µg/mL | |||||
| 27 | Halorosellinia sp. (No. 1403) | -- | South China Sea | SZ-685C (73) | NFPA, MMQ and RPC cells | 18.76, 14.51, and 56.09 µM | [47] |
| 28 | Dothiorella sp. | Aegiceras corniculatum | Fujian Province, China | Dothiorelone F (74), Dothiorelone G (75) | Raji cancer | 2 µg/mL | [49] |
| 29 | Rhytidhysteron sp. | Leaves of Azima sarmentosa | Samutsakhon province, Thailand | Rhytidones B–C (76, 77), MK3018 (78), palmarumycin CR1 (79) | MCF-7 and CaSki Cells | In the range of 14.47 and 25.59 µM | [50] |
| Rhytidones B (76) | CaSki | 22.81 µM | |||||
| 30 | Sporothrix sp. | Bark, Kandelia candel | South China Sea | Sporothrin A (80) | Inhibition of AChE in vitro | 1.05 µM | [51] |
| sporothrin B (81), sporothrin C (82), diaporthin (83) | HepG2 | 20, 23, and 23 µg/mL | |||||
| 31 | Eurotium rubrum | Semi-mangrove plant Hibiscus tiliaceus | Hainan Island, China | 12-demethyl-12-oxo-eurotechinulin B (84), 9-dehydroxyeurotinone (85), variecolorin G (86), alkaloid E-7 (87), and emodin (88) | HepG2, MCF-7, SW1990, HepG2, NCI-H460, SMMC7721, HeLa, and Du145 | In the range of 15–30 µg/mL | [52] |
| 32 | Bionectria ochroleuca | Inner leaf tissues of the plant Sonneratia caseolaris | Hainan island, China | Pullularins E (89), F (90), pullularins A (91), and C (92) | L5178Y | EC50 values In the range of 0.1 and 6.7 µg/mL | [53] |
| verticillin D (93) | L5178Y | <0.1 µg/mL | |||||
| 33 | Aspergillus sp. HN15-5D | Leaves, Acanthus ilicifolius | Hainan Island, China | Aspergisocoumrins A–B (94–95) | MDA-MB-435 | 5.08 and 4.98 µM | [54] |
| 34 | Aspergillus niger MA-132 | Avicennia marina | Hainan, China | Nigerasterol A (96) Nigerasterol B (97) | HL60 | 0.30 µM, 1.50 µM | [55] |
| Nigerasterol A (96) Nigerasterol B (97) | A549 | 1.82 and 5.41 µM | |||||
| 35 | Aspergillus nidulans MA-143 | Leaves, Rhizophora stylosa | Aniquinazolines A–D (98–101) | Brine shrimp | LD50 1.27, 2.11, 4.95 and 3.42 µM, (Colchicine LD50 88.4 µM | [56] | |
| 36 | Aspergillus terreus (No. GX7-3B) | Branch of Bruguiera gymnoihiza (Linn.) | South China Sea | 3β,5α-dihydroxy-(22E,24R)-ergosta-7,22-dien-6-one (102), Beauvericin (104) | MCF-7, A549, HeLa and KB | 4.98 and 2.02, 1.95 and 0.82, 0.68 and 1.14, 1.50 and 1.10 µM | [57] |
| 3β,5α,14α-trihydroxy-(22E,24R)-ergosta-7, 22-dien-6-one (103) | MCF-7, A549, HeLa and KB | 25.4, 27.1, 24.4, 19.4 µM | |||||
| 37 | Aspergillus terreus (No. GX7-3B) | Branch of Bruguiera gymnoihiza (Linn.) | South China Sea | Botryosphaerin F (105) and LL-Z1271β (106) | MCF-7 and HL-60 | 4.49 and 3.43 µM | [58] |
| HL-60 | 0.6 µM | ||||||
| 38 | Penicillium sp. J-54 | Leaves, Ceriops tagal | Hainan province, China | Penicieudesmol B (107), | K-562 | 90.1 µM, (paclitaxel, 9.5 µM) | [59] |
| 39 | Penicillium citrinum HL-5126 | Bruguiera sexangula var. rhynchopetala | South China Sea | Penibenzophenone B (108) | A549 Cells | 15.7 µg/mL | [60] |
| 40 | Penicillium sp. | Panax notoginseng | Wenshan, Yunnan province, China | Brefeldin A (109), Brefeldin A 7-O-acetate (110) | 293, HepG2, Huh7 and KB cell line | LD50 value from 0.024 to 0.62 µM. Both the compounds arrested HepG2 cells at the S phase | [61] |
| 41 | Penicillium chrysogenum V11 | Vein of Myoporum bontioides | Leizhou Peninsula, China | Penochalasin K (111) | MDA-MB-435, SGC-7901 and A549 cells | <10 µM | [62] |
| 42 | Penicillium janthinellum HDN13-309 | Sonneratia caseolaris | Hainan Province, China | Penicisulfuranols A–C (112–114) | HeLa and HL-60 Cells | In the range of 0.1 to 3.9 µM | [63] |
| 43 | Penicillium chrysogenum V11 | Not reported | Not reported | Penochalasin I (115), chaetoglobosins A (116), and cytoglobosin C (117) | MDA-MB-435 and SGC-7901 cells | <10 µM | [64] |
| Compounds (116), and (117) | SGC-7901 and A549 cells | <10 μM | |||||
| 44 | Penicillium brocae MA-231 | Mangrove plant Avicennia marina | Hainan Island, China | Spirobrocazine C (118) | A2780 | 59 µM | [65] |
| Brocazine G (119) | A2780 and A2780 CisR | 664 nM, 661 nM (cisplatin 1.67 and 12.63 µM) | |||||
| 45 | Penicillium brocae MA-231 | Mangrove plant Avicennia marina | Hainan Island, China | Brocazines A (120), B (121), E (122), F (123) | Du145, Hela, HepG2, MCF-7, NCI-H460, SGC-7901, SW1990, SW480, and U251 | from 0.89 to 9.0 µM | [66] |
| Compounds (120) and (121) | SW480 tumor cell line | 2.0 and 1.2 µM | |||||
| Compound (123) | DU145 and NCI-H460 Cells, | 1.7 and 0.89 µM | |||||
| 46 | Penicillium chermesinum strain HLit-ROR2 | Heritiera littoralis, | Samut Sakhon province, Thailand | TMC-264 (124) | T47D and MDA-MB231 | 1.08 and 2.81 µM (doxorubicin 1.55 and 2.24 µM) | [67] |
| HepG2 | 3.27 µM (Etoposide, 35.66 µM) | ||||||
| MOLT-3 | 1.36 µM | ||||||
| T47D | 1.08 µM | ||||||
| PR-toxin (125) | HuCCA-1, HeLa, T47D, and MDA-MB231 | 0.81–2.19 µM (doxorubicin, 0.26–2.24 µM) | |||||
| HL-60 cell line | 0.06 µM (doxorubicin, 1.21 µM) | ||||||
| MOLT-3 and HL-60 | 0.09 µM, 0.06 µM | ||||||
| 47 | Penicillium chrysogenum HND11-24 | The rhizosphere soil of the mangrove plant Acanthus ilicifolius | China | Penicitols A (126) | HeLa, BEL-7402, HEK-293, HCT-116, and A549 Cells | 4.6−10.5 µM | [68] |
| Penicitols B (127) | 3.4−9.6 µM | ||||||
| Penicitols C (128) and Penixanacid A (129) | In the range of 10–40.5 µM | ||||||
| 48 | Penicillium sp. FJ-1 | Avicennia marina | Fujian, China | Compound (130) | Tca8113 and MG-63 cells | 26 and 35 µM (Taxol, 46 and 10 nM) | [69] |
| Compounds (131) | Tca8113 and WRL-68 | 10 and 58 µM | |||||
| Compounds (131) | MG-63 cells | 55 nM | |||||
| 49 | Penicillium sp. GD6, | Bruguiera gymnorrhiza | Zhanjiang, China | Meleagrin (132) | HL60 and A549 | 9.7 and 8.3 µM | [70] |
| 50 | Penicillium 303# | Sea water | Guangdong Province, China | 5S, 7R, 9S, 10S, 11R, 12S, 13R, 22R, and 23R. (133), 7R, 9S, 10S, 11R, 12S, 13R, 22R, and 23R (134) | MDA-MB-435, HepG2, HCT-116, and A549 | In the range of 11.9–37.82 µg/mL | [71] |
| Compounds (135) | MDA-MB-435 | 7.13 | |||||
| Compound (136) | HepG2 and HCT-116 | 39.64 and 27.80 µM | |||||
| 51 | Penicillium sp. ZH58 | Leaves, Avicennia sp. | Dong Sai, Hainan of the South China Sea coast | 4-(methoxymethyl)-7-methoxy-6-methyl-1(3H)-isobenzofuranone (137) | KB and KBV200 cells | 6 and 10 µg/mL | [72] |
| 52 | Penicillium sumatrense MA-92 | Rhizosphere, Lumnitzera racemose | WenChang in Hainan Island, China | Sumalarins A–C (138, 139, 140), and dehydrocurvularin (141) | Du145, HeLa, Huh 7, MCF-7, NCI-H460, SGC-7901, and SW1990 Cells | In the range of 3.8 to 10 µM | [73] |
| 53 | Penicillium sp. ZH16 | Avicennia sp. | South China Sea | 5-methyl-8-(3-methylbut-2-enyl) furanocoumarin (142) | KB and KBV200 | 5 and 10 µg/mL | [74] |
| 54 | Trichoderma sp. 307 | Stem bark, Clerodendrum inerme | Guangdong Province, China | (3S)-6-oxo-de-O-methyllasiodiplodin (143) | GH3 and MMQ Cells RPC | 21.42 and 13.59 µM, 142.8 µM | [75] |
| Co cultured with Acinetobacter johnsonii B2 | (3R)-de-O-methyllasiodiplodin (144) | 6.44 and 6.58 µM, 6.94 µM | |||||
| (3R)-nordinone (145) | 12.33 and 10.13 µM, 100.03 µM. | ||||||
| 55 | Trichoderma sp. 307 co-culturing with Acinetobacter johnsonii B2 | Stem bark of Clerodendrum inerme | Guangdong Province, China | Botryorhodine H (146) | MMQ GH3 Cells | 3.09 and 3.64 µM | [76] |
| 56 | Trichoderma sp. Xy24 | Leaves, stems and peels of Xylocarpus granatum | Hainan province, China | (9R,10R)-dihydro-harzianone (147) | HeLa and MCF-7 Cells | 30.1 µM and 30.7 µM | [77] |
| 57 | Nigrospora sp. MA75 | Pongamia pinnata | Guangxi Zhuang Autonomous Region of China | 2,3-didehydro-19α-hydroxy-14-epicochlioquinone B (148) | MCF-7, SW1990, and SMMC7721 | 4, 5, and 7 µg/mL | [78] |
| 58 | Fusarium sp. (No. DZ27) | Bark of Kandelia candel | Dongzhai mangrove, Hainan, China | Beauvericin (104) | KB and KBv200 cells | 5.76 and 5.34 µM | [79] |
| 59 | Fusarium sp. | Leaf of mangrove Kandelia candel | Dongzhai Harbor of Hainan Island, China | Apicidin (149) | GLC-82 cells | 6.94 µM | [80] |
| 60 | Unidentified fungus ZZF42 | South China Sea | Not reported | Apicidin (149) | KB and KBv200 | 0.78 µg/mL | [81] |
| 61 | Fusarium incarnatum (HKI0504) | Aegiceras corniculatum | Not reported | 2-acetyl-1,2,3,4-tetrahydro-β-carboline (150) | HUVEC and K-562 | GI50 41.1 and 33.3 | [82] |
| HeLa cell | CC50 23.8 µM | ||||||
| Fusarium incarnatum (HKI0504) | Aegiceras corniculatum | Not reported | Fusamine (151) | HUVEC and K-562 | GI50 37.3 and 37.6 | [82] | |
| HeLa cell | CC50 23.3 µM | ||||||
| Fusarium incarnatum (HKI0504) | Aegiceras corniculatum | Not reported | 3-(1-aminoethylidene)-6-methyl-2H-pyran-2,4(3H)-dione (152) | HUVEC and K-562 | GI50 41.1 and 33.3 | [82] | |
| HeLa cell | CC50 23.8 µM | ||||||
| 62 | Acremonium sp. | leaves of Sonneratia caseolaris c | Dong Zhai Gang Mangrove Garden, Hainan, China | Torrubiellin B (153) | Cisplatin sensitive Cal27, Kyse510, HCC38, A2780, MDA-MB-231 | In the range of 0.3 to 1.5 µM | [83] |
| Cisplatin resistant, Cal27, Kyse510, HCC38, A2780, MDA-MB-231 | In the range of 0.2 to 2.6 µM | ||||||
| 63 | Acremonium strictum | Rhizophora apiculata | Island of Cat Ba, Vietnam | Waol A (154), Pestalotiopene A (155) Cytosporone E (156) | Cisplatin-sensitive, A2780 | 27.1, 76.2, and 8.3 µM | [84] |
| Cisplatin-Resistant A2780 | 12.6, 30.1, and 19.0 µM | ||||||
| 64 | Endophytic fungus J3 | Ceriops tagal | Hainan province, China | 3,4-seco-sonderianol (157) | K562, SGC-7901, and BEL-7402 Cells | 9.2, 15.7, and 25.4 µg/mL | [85] |
| 65 | Endophytic fungus No. ZH-3 | Not reported | South China Sea | 2-(3-chloro-2, 6-dihydroxy-4-methylbenzoyl)-5-hydroxy-3-methoxybenzoate (158) | HepG2 cell line | 25 µg/mL | [86] |
| 66 | Endophytic fungus No. 5094 | Not reported | South China Sea | Anthracene derivative (159) | KB and KBv200 | LD50 values of 5.5 and 10.2 µM | [87] |
| 67 | Co-cultures of two mangrove endophytic fungi (strains Nos. 1924 and 3893) | Not reported | Marinamide (160) | HepG2, 95-D, MGC832 and HeLa Cells | 7.0, 0.4, 91 nM and 0.529 µM | [88] | |
| Methyl marinamide (161) | HepG2, 95-D, MGC832 and HeLa Cells | 2.52, 1.54 13, 0.110 µM | |||||
| 68 | Endophytic fungus No·Gx-3a | Not reported | South China sea | Ditryptophenaline (162) | KB, KBv200 | 8.0 and 12.0 µM | [89] |
| 69 | Mangrove endophytic fungus No·SK7RN3G1 | Not reported | South China Sea | 3,8-dihydroxy-6-methyl-9-oxo-9H-xanthene-1-carboxylate (163), Lichenxanthone (164), | HepG2 cell line | 20 and 25 µg/mL | [90] |
| Compounds Produced by Basidiomycetes | |||||||
| 70 | Basidiomycetous fungus XG8D | leaves of Xylocarpus granatum | Samutsakorn province, Thailand | Merulinols C and D (165, 166) | KATO-3 cells | 35.0 and 25.3 µM | [91] |
| 71 | Pseudolagarobasidium acaciicola, | Bruguiera gymnorrhiza | Samut Sakhon province, Thailand | Compound (167) | HuCCA-1, A549, MOLT-3, HepG2, MDA-MB231, T47D | 0.28–37.46 µM | [92] |
| MRC-5 | IC50 17.92 µM | ||||||
| HL-60 cell line | IC50 0.28 µM | ||||||
| Compound (168) | A549, MOLT-3, HepG2, HL-60, MDA-MB231, T47D, HeLa cancer cell, MRC-5 | 12.09–170.08 µM | |||||
| Compound (169) | HuCCA-1, A549, MOLT-3, HepG2, HL-60, MDA-MB231, T47D, HeLa cancer cell | 15.20–76.97 µM | |||||
| Compound (170) | HuCCA-1, A549, MOLT-3, HepG2, MDA-MB231, T47D, HeLa cancer cell | 18.31–154.51 µM | |||||
| HL-60 | 18.31 µM | ||||||
| 72 | Pseudolagarobasidium acaciicola | Bruguiera gymnorrhiza | Not reported | Endoperoxide (171), Steperoxide A (172) | MOLT-3, HuCCA-1, A549, HepG2, HL-60, MDA-MB-231, T47D, and HeLa cancer Cells | In the range of 0.68–3.71 and 0.67–5.25 µg/mL | [93] |
| Merulin B (173) | MOLT-3, A549, HepG2, HL-60, MDA-MB-231 and T47D Cells | In the range of 11.94–49.08 µg/mL | |||||
| Merulin C (174) | HL60 cancer cells | 0.08 µg/mL | |||||
| MOLT-3, HuCCA-1, A549, HepG2, MDA-MB-231, T47D, and HeLa Cells | In the range of 0.19–3.75 µg/mL | ||||||
| 73 | Mucor irregularis QEN-189 | Rhizophora stylosa | Hainan Island, China | Rhizovarins A, B, E (175, 176, 177) Penitrems A, C, F (178, 179, 180) and 3β-hydroxy-4β-desoxypaxilline (181) | A-549 | 11.5, 6.3, 9.2, 8.4, 8.0, 8.2 and 4.6 µM | [94] |
| Rhizovarins A, B, (175, 176), Penitrems A, C, F (178, 179, 180) and 3β-hydroxy-4β-desoxypaxilline (181) | HL-60 | 9.6, 5.0, 7.0, 4.7, 3.3 and 2.6 µM | |||||