Table 3.
Population genetic analysis of the newly discovered IL-6 SNPs −663 (A > G), −447 (C > G), −357 (G > A), and 3177 (C > T).
| No | Mutation Site | Sample Size | Genotype Frequency 1 | Gene Frequency | χ2 | p-Value | PIC | H | Ne | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | A-663G | 220 | AA: 0.000 (0) | GG: 1.000 (220) | AG: 0.000 (0) | A: 0.000 | G: 1.000 | 0.000 | 0.000 | 1.000 | ||
| 2 | C-447G | 220 | CC: 0.455 (100) | GG: 0.090 (20) |
GC: 0.455 (100) | C: 0.680 | G: 0.320 | 0.500 | 0.799 | 0.340 | 0.434 | 1.766 |
| 3 | G-357A | 220 | GG: 0.290 (64) | AA: 0.255 (56) |
GA: 0.455 (100) |
G: 0.518 | A: 0.482 | 1.770 | 0.413 | 0.375 | 0.499 | 1.997 |
| 4 | C3177T | 220 | CC: 0.400 (88) | TT: 0.145 (32) | CT: 0.455 (100) | C: 0.627 | T: 0.373 | 0.170 | 0.918 | 0.358 | 0.468 | 1.878 |
1 The number in brackets is the sample size. PIC: Polymorphism information content, H: Heterozygosity, Ne: Effective number of allele.