Table 5.
Changes in transcription factors before and after SNP mutation in the promoter region of the chicken IL-6 gene.
| Mutation Site | Base Group | Transcription Factor | Transcription Factor Binding Site Base Sequence | Transcription Factor Position |
|---|---|---|---|---|
| −357 | G | Sp1 | gacacgccacacc | −360–(−348) |
| A | ||||
| −447 | C | HB | cttaaaaacg | −447–(−438) |
| G | C/EBPα | aaacggttaa | −452–(−443) | |
| −458 | T | MEB-1 GLO |
ttttttaaac ttttttaaac |
−458(−449) −458–(−449) |
| G | Sp1 | ccgaggaggg | −467–(−458) | |
| −483 | A | PU.1 GATA-1 C/EBPα |
aaaagagaac aaatgaaaag acaaatgaaa |
−483–(−474) −488–(−479) −490–(−481) |
| G | PU.1 ISGF-3 TEC1 IRF-1 |
gaaagagaac ggaaagagaa ggaaagagaa ggaaagagaa |
−483–(−474) −484–(−475) −484–(−475) −484–(−475) |
|
| −511 | C | TBP | tgcttataag | −513–(−504) |
| T | TBP ICS BP |
atgtttataa agtttcatgt |
−514–(−505) −520–(−511) |
|
| −610 | G | Sp1 | ggagcgatgg | −615–(−606) |
| A | ||||
| −634 | A | GR Sp1 |
cactgtgtgc cctccaccact |
−635–(−626) −642–(−632) |
| G | ||||
| −663 | A | |||
| G | AP-2α Sp1 Sp1 |
cccggggagc gccccggggag cctgctgccccggg |
−668–(−659) −670–(−660) −676–(−663) |
|
| −1208 | A | Sp1 | ggctcggggagccag | −1221–(−1207) |
| G | Sp1 | ggggagccgggc | −1216–(−1205) | |
| −1220 | G | Sp1 C/EBPβ |
ggctcggggagccag gctgtggctc |
−1221–(−1207) −1226–(−1217) |
| T | ||||
| −1223 | G | C/EBPβ C/EBPα |
gctgtggctc ataattgctg |
−1226–(−1217) −1232–(−1223) |
| A | ||||