Skip to main content
. 2018 Aug 21;9(9):421. doi: 10.3390/genes9090421

Figure 3.

Figure 3

Effect of A23187 on gene expression. Patients’ skin fibroblasts were incubated with DMSO (untreated), 1 µM or 10 µM of A23187 for 4 h, 24 h, and 48 h. (a) FOS gene expression. (b) FBN1 gene expression after treatment with A23187 (Control vs. 4 h: p-value = 0.0082; Control vs. 24 h: p-value < 0.0001; Control vs. 48 h: p-value < 0.0001). (c) FBN1 gene expression according to rs11212346 genotype (Control vs. 4 h: p-value = 0.0906; Control vs. 24 h: p-value = 0.0075; Control vs. 48 h: p-value < 0.0001). Genotype: [CC] (n= number of subject); [CT] (n); [TT] (n). [NS] p-value > 0.05; ** p-value < 0.01; *** p-value < 0.001; **** p-value < 0.0001.