Table 2.
Distribution of the types of microenvironment in LADC age-stratified specimens based on the PD-L1 expression in tumor cells or in immune cells, and on the density of TAICs. The Fisher’s exact test was used.
| TAICs Density | Age < 75 Years | Age ≥ 75 Years | ||||
|---|---|---|---|---|---|---|
| PD-L1 Expression in Tumor Cells Negative | PD-L1 Expression in Tumor Cells Positive | p-Value | PD-L1 Expression in Tumor Cells Negative | PD-L1 Expression in Tumor Cells Positive | p-Value | |
| CD8+ cells | < 0.001 | 0.256 | ||||
| Negative | 25 (34%) | 11 (15%) | - | 9 (33%) | 5 (19%) | - |
| Positive * | 11 (15%) | 26 (36%) | - | 5 (19%) | 8 (30%) | - |
| CD4+ cells | 0.004 | 0.236 | ||||
| Negative | 26 (36%) | 14 (19%) | - | 7 (26%) | 3 (11%) | - |
| Positive * | 10 (13%) | 23 (32%) | - | 7 (26%) | 10 (37%) | - |
| CD4+/CD8+ ratio | 0.814 | 0.999 | ||||
| Negative | 20 (27%) | 22 (30%) | - | 4 (15%) | 4 (15%) | - |
| Positive | 16 (22%) | 15 (21%) | - | 10 (37%) | 9 (33%) | - |
| CD33+ cells | 0.019 | 0.695 | ||||
| Negative | 23 (32%) | 13 (18%) | - | 8 (30%) | 5 (19%) | - |
| Positive * | 13 (18%) | 24 (33%) | - | 6 (25%) | 7 (26%) | - |
| PD-L1 stromal cells | < 0.001 | 0.001 | ||||
| Negative | 30 (41%) | 5 (7%) | - | 12 (44%) | 2 (7%) | - |
| Positive * | 6 (8%) | 32 (44%) | - | 2 (7%) | 10 (37%) | - |
* Median PD-L1 expression in tumor cells and median TAICs determined by CD8, CD4, PD-L1 stromal, and CD33 cell densities were defined as positive.