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Effect of other SPATEs on active ion transport in HCM and human enteroid monolayers (HEM). (A) SepA—stimulated ion secretion is CFTR-mediated and completely inhibited by CFTRinh-172 (25 µM). Blue arrows show the time points of each SepA addition (10 µg/mL) as well as addition of CFTRinh-172. Neither Pic (10 µg/mL) (B) nor EatA (10 µg/mL) (C) stimulated Isc in proximal UD HCM or jejunal HEM, respectively. Blue arrows indicate the time points of Pic or EatA addition.
