Figure 7.

Scheme of the IDC signaling cascade. PDC1 encodes a repressor of the cascade, which was shown to likely repress the positive regulatory loop of the PaMpk1 MAPK cascade [45]. Double mutants of PDC1 and either PaMpk1 or PaMpk2 never present CG. On the contrary, double mutants lacking PDC1 and either one of the upstream IDC proteins may exhibit CG sectors during growth since the positive regulatory loop is not repressed, yet these are not induced by passage into stationary phase, because the signal between the PaNox1 complex and the MAPK is not transmitted.