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The regulation of EZH2 and related pathologies by the ubiquitin proteasomal system. Composition of the E3 complex and DUB targets EZH2. The Skp-1- Cullin-1-F-Box (SCF) E3s are multimeric E3 ligases that mediates the ubiquitin (Ub) transfers from E2 conjugating enzymes to EZH2.
