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. 2018 Jul 14;5(3):39. doi: 10.3390/jcdd5030039

Table 3.

Post-translational modifications (PTM) of ANGPTL3.

PTM Position(s) Enzyme Ref.
N-glycosilation N115 GlcNAc [1,37]
O-glycosilation T226 GalNAc-T2 [36]
Disulfide bond C246 ↔ C274 [1]
N-glycosilation N296 GlcNAc [37,38]
N-glycosilation N357 GlcNAc [37]
Disulfide bond C394 ↔ C408 [1]

In bold are the PTM that preserve ANGPTL3 from PC’s proteolytic cleavage.