Acute Leukaemias |
ALL |
BCR/abl fusion protein |
[76] |
TEL-JAK2 fusion protein |
[77] |
|
AML |
Aberrant exogenous cytokine signaling |
[75] |
Constitutive Protein Tyrosine Kinases (PTK) activation without exposure to exogenous cytokines |
[75] |
Activating STAT3 mutations |
[21] |
Hypermethylation, hence, silencing of negative regulators of STAT3 (PIAS3, SOCS3 and PTP) |
[21] |
Chronic Leukemias |
CLL |
Casein Kinase2(CK2)-B cell linker (BLNK)-CD5 complex causes constitutive phosphorylation |
[79] |
|
CML |
JAK activation by bone marrow microenvironment |
[78] |
Lymphomas |
HL |
Activating mutations in JAK1 and STAT3 |
[80] |
Autocrine secretion of IL13 by HRS cells |
[82] |
|
NHL |
Autocrine and paracrine secretion of IL6 and IL13 |
[81,83] |
Multiple Myeloma |
- |
Autocrine and paracrine secretion of IL6 and subsequent activation of JAK1 |
[62] |
Overexpression and hyperactivation of CK2 |
[84] |