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. 2018 Sep 14;7(9):138. doi: 10.3390/cells7090138

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Genomic organization of the DLK1–DIO3 domain. (A) The region is located on chromosome 14q32.2. (B) It contains three paternally expressed protein-coding genes (DLK1, RTL1, and DIO3), three maternally expressed noncoding genes (MEG3, MEG8, and antisense RTL1), many snoRNAs, and a large cluster of 54 miRNAs (striped bar). (C) The expression within the region is under the control of MEG3-DMR that overlaps with the promoter and the 5′-end of the MEG3 gene. MEG3-DMR contains several CTFC binding sites (gray bars) and CpG islands (black bars). (D) The schema shows localization of amplicons (A1–A3) in the region that were used for methylation analyses.