Table 1.
Clinical characteristics of patients and their stratification according to expression activity in the DLK1–DIO3 locus.
| Variable | Patients with Baseline miRNA Expression | Patients with Increased miRNA Expression | p-Value | |
|---|---|---|---|---|
| Age (years) | Mean (range) | 73 (65–88) | 69 (63–81) | 0.294 |
| Sex, n | Male | 4 | 2 | 0.248 |
| Female | 2 | 4 | ||
| Karyotype, n | Normal | 2 | 1 | 0.505 |
| Abnormal | 4 | 5 | ||
| Marrow blasts | Mean (range) | 10.4 (5.1–20.0) | 31.6 (18.0–75.0) | 0.048 |
| Diagnosis, n | MDS | 6 | 1 | 0.015 |
| AML-MRC | 0 | 5 | ||
| IPSS, n | Intermediate-1/2 | 3 | 0 | 0.182 |
| High | 3 | 6 | ||
| Response to AZA therapy | ORR, n (%) | 3 (50%) | 4 (67%) | 0.558 |
IPSS—International Prognostic Scoring System, ORR—overall response rate.