Table 4.
Antiviral activity of TB-EO, geraniol, and TB-EO with ACV in combination against HSV-2 replication.
| Test Compounds | CC50 (µg/mL) | EC50 (µg/mL) | SI |
|---|---|---|---|
| TB-EO | >210 | 2.13 ± 0.63 | >98.59 |
| Geraniol | >210 | 1.92 ± 0.84 | >109.38 |
| TB-EO combined with ACV | >210 | 0.81 ± 1.21 | >259.26 |
| ACV | >210 | 1.94 ± 0.41 | >108.25 |
Values demonstrated are means ± standard deviation (SD) of three independent experiments conducted in duplicate. TB-EO: T. bovei essential oil; ACV: Acyclovir; CC50: 50% cytotoxic concentration; EC50: 50% effective concentration; SI: Selectivity index (calculated as the ratio CC50/EC50). Experiments were performed in duplicate in three independent experiments. PRISM software version 5.0 (GraphPad Software, Inc., La Jolla, CA, USA) was used for statistical analysis (one-way ANOVA test) and to calculate EC50 and CC50 parameters.