Table 1.

NFKB1 SNPs (Single Nucleotide Polymorphisms) associated with cancer. NFKB1 polymorphisms in different c-94ancer types are associated with either an advantageous or disadvantageous prognosis in different population cohorts.

SNP	Cancer Type	Sequence; Location; Consequence (If Known)	Prognostic	Cohort	Reference
rs28362491	Colorectal	ATTG del; -94 promoter region; reduces promoter activity and nuclear protein binding ability, decreasing NFKB1 expression	Disadvantageous	Swedish; Malaysian	[68,69]
	Gastric		Disadvantageous	Japanese; Chinese	[36,37]
	Liver		Disadvantageous	Taiwanese	[70]
	Bladder		Disadvantageous	Chinese	[71]
	Esophageal		Disadvantageous	Northern Indian	[72]
	Thyroid		Disadvantageous	Chinese	[73]
	Melanoma		Disadvantageous	Brazilian, Swedish	[74,75]
	Nasopharyngeal		Disadvantageous	Chinese	[76]
	Oral		Disadvantageous	Taiwanese	[77]
	Prostate		Advantageous	Canadian	[78]
	Ovarian		Advantageous	Greek	[55]
	Cervical		Advantageous	Chinese, Indian	[79,80]
rs230496	Liver	AG and GG genotypes	Disadvantageous	Chinese	[81]
rs230525	Liver	GA genotypes	Disadvantageous	Chinese	[81]
rs230530	Liver	AA genotypes	Disadvantageous	Chinese	[81]
rs78696119	Gastric	GG genotypes; increased inflammatory cell infiltration, diffuse type gastric cancer and cancer progression	Disadvantageous	Japanese	[36]
rs72696119	Gastric	GG and del/del genotypes; -449 in 5′ UTR region; muscle layer tumour invasion and lymph node metastasis	Disadvantageous	Japanese	[36]
rs4648068	Gastric	GG genotype; intron 12; increased incorporation of the H3K9me1 and H3K4me1 histones, increased chemomodification, enhanced transcriptional activity, cell proliferation and motility	Disadvantageous	Chinese	[37,82]
rs230510	Gastric	A genotype; intronic region	Advantageous	Japanese, US	[83]
	Ovarian	T genotype; intron 12	Advantageous	Chinese	[84]
rs230521	Ovarian	G genotype; intron 4	Advantageous	Chinese	[84]