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. 2018 Aug 27;7(9):119. doi: 10.3390/cells7090119

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Nlrp12 does not affect the differentiation of naïve CD4⁺ T cells to Th1 or Th17. Naïve CD4⁺ T cells from WT and Nlrp12^−/− mice were purified and stimulated with MOG-splenocytes in the presence of Th1 or Th17 polarizing cytokines for 3 days. After 5 h stimulation with PMA/ionomycin, cells were stained for Vβ11 and Th1- or Th17- associated cytokine/transcription factor and analyzed by flow cytometry, n = 3; Representative flow cytometric plots show the expression of Th1- and Th17-related markers in Vβ11⁺ T cells.