Table 8.
Diagnostic accuracy of either miRNA or SGA alone and dual analysis of both markers in detection of cachexia in various models. (BW–body weight, PPV–positive predictive value, NPV–negative predictive value).
| Cachexia Model | Sensitivity | Specificity | PPV | NPV | |
|---|---|---|---|---|---|
| miRNA | Loss >5% of BW | 77.1% | 71.4% | 73% | 75.8% |
| SGA-C | 42.9% | 71.4% | 60% | 55.6% | |
| SGA-C + miRNA | 88.6% | 94.3% | 93.9% | 89.2% | |
| miRNA | high TNF-α + loss >5% of BW | 88% | 45% | 70.7% | 78.6% |
| SGA-C | 50% | 60% | 61.9% | 52% | |
| SGA-C + miRNA | 84.6% | 90% | 92.3% | 90% | |
| miRNA | Loss >10% of BW | 91.3% | 66% | 56.8% | 93.9% |
| SGA-C | 39.1% | 66% | 64% | 68.9% | |
| SGA-C + miRNA | 91.3% | 91.5% | 84% | 95.6% | |
| miRNA | high TNF-α + loss >10% of BW | 94.7% | 50% | 58.1% | 92.9% |
| SGA-C | 47.4% | 53.8% | 57.1% | 58.3% | |
| SGA-C + miRNA | 94.7% | 84.6% | 81.8% | 95.6% | |