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. 2018 Sep 3;10(9):305. doi: 10.3390/cancers10090305

Figure 2.

Figure 2

Overexpressed Prx II regulates stemness-associated properties of HCC cells. (A) Activation of VEGF/VEGFR2/STAT3 signaling via overexpressed Prx II-mediated stimulation of VEGF, to induce stemness gene expression such as SOX2, EpCAM and Keratin 19 and maintenance of stem cell properties. (B) Inducing Cyclin D1 by overactivation of Ras/Raf/MEK/ERK/FoxM1 pathway to induce stemness properties of HCC. (C) Additionally, the transcriptional activation of Prx II by overexpressed FoxM1 transcription factor. (D) Inhibition of oxidative stress and upregulation of stemness-associated properties by targeting ROS.