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. 2018 Sep 3;10(9):305. doi: 10.3390/cancers10090305

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Prx II-mediated stemness-associated properties in gastric cancers. (A) Transcriptionally silenced expression of Prx II in gastric cancer cells by hypermethylation of CPG islands in promoter regions of Prx II. (B) ROS level is increased by silenced Prx II and Increased ROS induces the hypermethylation of CPG islands. (C,D) Reduced cell autonomous apoptosis and apoptosis via inhibiting caspase activities by silenced Prx II. (E,F) Over activation of c-Src kinase and H₂O₂ level by silenced Prx II, which then promotes the stemness-associated properties.