Figure 6.

Stemness-associated properties and radiosensitivity are mediated by Prx II in breast cancers. Up-expression of Prx II in breast cancers induces the consequence expression of protein thiol (PSH) and glutathione (GSH). These expressions are associated with decreased cellular toxicity by induced Ca²⁺ efflux and Ca²⁺ homeostasis. Cellular toxicity reduction induces the stemness-associated properties of CSCs and decreases the sensitivity to radiotherapies. Prx II also protects lung metastatic breast cancer cells from ROS-mediated oxidative stress in lung microenvironment.