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Prx II-mediated prostate cancer progression promotes stemness-associated properties. Prx II is localized both in cytosol and nucleus in AR-expressing prostate cancer cells and castration-resistant prostate cancer (CRPC) cells. Overexpression of Prx II in cytosol induces AR transactivation whereas inhibits in nucleus. Distinct regulation of AR transactivation induces the growth of AR-expressing prostate cancers, stemness-associated properties and formation to CRPCs.
