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. 2018 Jul 26;6(3):20. doi: 10.3390/jdb6030020

Table 1.

Matrix metalloproteinases (MMPs), their known extracellular matrix substrates, and the placodal systems in which their substrates have been studied. Modified from Reference [11].

MMP Substrate Placodal Systems
1 Collagens (I, II, III, VII, VIII, X and XI), entactin, proteoglycans, ovostatin, MMP2, MMP9, pro-MMP9, fibronectin, vitronectin, laminin, tenascin, aggrecan, link protein, myelin basic protein, versican Tooth, feather, otic, lens
2 Collagens (I, II, III, IV, V, VII, X and XI), gelatin, elastin, fibronectin, vitronectin, laminin, entactin, tenascin, SPARC, aggrecan, link protein, galectin-3, versican, decorin, myelin basic protein Hair, feather, mammary gland, tooth, lens, otic
3 Collagens (III, IV, V, VII, IX, X and XI), gelatin, aggrecan, laminin, elastin, casein, osteonectin, fibronectin, ovostatin, entactin, plasminogen, pro-MMP9, vitronectin, tenascin, SPARC, link protein, decorin, myelin basic protein, perlecan, versican, fibulin Mammary gland, tooth, feather, otic, lens
7 Collagens (I and IV, gelatin, fibronectin, laminin, elastin, transferrin, casein, vitronectin, SPARC, aggrecan, decorin, versican, fibulin, myelin basic protein Hair, feather, lens
8 Collagens (I, II and III), fibronectin, proteoglycans, aggrecan feather, lens
9 Collagens (IV, V, VII, X and XIV), gelatin, elastin, fibronectin, vitronectin, laminin, SPARC, aggrecan, link protein, galectin-3, versican, decorin, myelin basic protein Hair, feather, tooth, lens, otic
10 Collagens (III, IV, V), gelatin, casein, elastin, fibronectin, aggrecan, link protein feather, lens
11 Collagen IV, laminin, elastin, fibronectin, casein, proteoglycans Feather, otic, lens
12 Collagen IV, elastin, gelatin, casein, fibronectin, vitronectin, laminin, entactin, fibrinogen Feather, otic, lens
13 Collagens (I, II, III, IV, VI, IX, X and XIV), large tenascin-C, plasminogen, aggrecan, fibronectin, SPARC, gelatin, perlecan
MMP9
Lens, feather
14 Collagens (I, II and III), gelatin, fibronectin, laminin, vitronectin, entactin, pro-MMP2, aggrecan, perlecan, Mammary gland, salivary gland, feather, otic, lens
15 Fibronectin, gelatin, vitronectin, entactin, laminin, pro-MMP2, tenascin, perlecan Mammary gland, salivary gland, otic, feather, lens
16 Collagen III, gelatin, casein, fibronectin, pro-MMP2, laminin, vitronectin Feather, otic, lens
17 Gelatin, fibrinogen, pro-MMP2
18 Collagen I
19 Collagens (I and IV), gelatin, fibronectin, laminin, entactin, large tenascin-C, fibronectin Feather, otic, lens
20 Amelogenin, aggrecan
21 Gelatin, casein
23 (A, B) Gelatin
24 Fibronectin, pro-MMP2, proteoglycans, gelatin Feather, lens
25 Collagen IV, gelatin, fibronectin, pro-MMP2, pro-MMPp Feather, lens
26 Collagen IV, fibrinogen, fibronectin, gelatin, pro-MMP9, vitronectin feather
27 Gelatin, casein
28 Casein