Table 2.
Study design, cellular model, and neuronal cell types.
| Ref. | Study Design | SCZ vs. Controls | Model | Major Cell Type(s) |
|---|---|---|---|---|
| [75] | Familial SCZ | 4 vs. 3 | iPSC | Forebrain, mixed glutamatergic-GABAergic neurons and NPCs |
| [76] | [75] | 4 vs. 3 | iPSC | Forebrain, mixed glutamatergic- GABAergic neurons |
| [77] | [75] | 4 vs. 6 | iPSC | Forebrain NPCs |
| [78] | Paranoid SCZ | 3 vs. 2 | iPSC | Midbrain dopaminergic and forebrain glutamatergic neurons |
| [79] | [75] | 4 vs. 3 | iPSC | Forebrain, mixed glutamatergic-GABAergic neurons |
| [80] | [75] | 4 vs. 3 | iPSC | FOXA2-positive midbrain dopaminergic neurons |
| [81] | [75] | 4 vs. 3 | iPSC | Dentate gyrus-like granule neurons |
| [82] | [75] | 4 vs. 3 | iPSC | CA3 and dentate gyrus neurons |
| [83] | CR-SCZ | 1 vs. 1 | iPSC | Retinoic acid-induced NPCs |
| [70] | [75] | 4 vs. 6 | iPSC | Forebrain NPCs |
| [84] | [78] | 1 vs. 1 | iPSC | Forebrain glutamatergic neurons |
| [85] | MIR137 risk alleles | 3 mar vs. 3 mir | iNLC | Early neuron-like cells FACS-purified |
| [55] | MIR137 risk SNP | 2 vs. 1 vs. 2 ig | iPSC | Induced forebrain glutamatergic neurons |
| [86] | [75] | 4 vs. 6 | iPSC | Forebrain NPCs |
| Childhood-onset SCZ | 10 vs. 10 | iPSC | Forebrain NPCs | |
| [87] | [75] | 3 vs. 3 | iPSC | Neuron committed forebrain NPCs |
Abbreviations are: CR-SCZ, Clozapin resistant patient with SCZ; FACS, fluorescence activated cell sorting; ig, isogenic cell line; iNLC, induced neuron-like cell; iPSC, induced pluripotent stem cell; mar, major risk allele; mir, minor risk allele; NPC, neural progenitor cell.