Table 5.

Association between combinations of MetS components and breast cancer risk by menopausal status (HR, 95% CI).

MetS Component Combinations	Overall (N = 94,555, Cases = 5380) b	Postmenopausal (N = 90,662, Cases = 5174)	Premenopausal (N = 3693, Cases = 196)
High blood pressure, high WC and diabetes	1.15 (0.93, 1.43)	1.11 (0.90, 1.38)	1.18 (0.28, 4.92)
Elevated cholesterol, diabetes, and high WC	1.15 (0.86, 1.53)	1.10 (0.82, 1.48)	1.14 (0.15, 8.87)
High blood pressure, diabetes and elevated cholesterol	1.04 (0.80, 1.34)	1.02 (0.79, 1.32)	0.60 (0.08, 4.42)
High blood pressure, elevated cholesterol and high WC	1.12 (0.97, 1.29)	1.09(0.94, 1.26)	0.79 (0.34, 1.79)

Models were adjusted for age, race, BMI, education, region, physical activity, smoking, marital status, family history of breast cancer, ovary status, hysterectomy, hormonal therapy use, and ovary status × BMI interaction. Women without the respective combination of the components were the referent in each analysis. ^b cases = number of incident breast cancer. Abbreviations: WC, waist circumference.