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Genetic alterations in mesenchymal GBM and their effect on NF-κB. Loss of NF1 and PTEN are characteristic findings in mesenchymal GBM. In addition, IDH1 mutation is the defining alteration of IDH-mutant GBMs that cluster transcriptionally with PN tumors. The effect of these genetic changes on NF-κB activation is demonstrated, as is the effect of these alterations on the tumor microenvironment.
