Table 5.
Clinical correlation of COMT polymorphism with respect to clinicopathological characteristics of CAD patients and controls.
| Allele/Genotype | Number | G/G (Val/Val) | A/G (Val/Met) | A/A (Met/Met) | p Value |
|---|---|---|---|---|---|
| COMT G > A correlation with sex | |||||
| Men | 96 | 09 | 68 | 19 | 0.53 |
| Women | 4 | 01 | 02 | 01 | |
| COMT G > A correlation with age | |||||
| ≤50 years | 47 | 03 | 27 | 17 | 0.0480 |
| >50 years | 53 | 07 | 43 | 03 | |
| COMT G > A correlation with RBS | |||||
| ≤140 mg | 55 | 03 | 45 | 7 | 0.016 |
| >140 mg | 45 | 07 | 25 | 13 | |
| COMT G > A correlation with cholesterol | |||||
| ≤200 mg | 93 | 09 | 69 | 15 | NS |
| >200 mg | 07 | 01 | 01 | 05 | |
| COMT G > A correlation with HDL | |||||
| ≤40 mg | 91 | 08 | 65 | 18 | NS |
| >40 mg | 9 | 02 | 05 | 02 | |
| COMT G > A correlation with LDL | |||||
| ≤100 mg | 79 | 07 | 58 | 14 | NS |
| >100 mg | 21 | 03 | 12 | 06 | |
| COMT G > A correlation with TGL | |||||
| ≤150 mg | 51 | 08 | 40 | 03 | <0.006 |
| >150 mg | 49 | 02 | 30 | 17 | |
| Correlation with hypertension | |||||
| Hypertension | 14 | 02 | 08 | 04 | NS |
| No hypertension | 86 | 08 | 62 | 16 | |
| Correlation with diabetes | |||||
| Diabetes | 23 | 04 | 13 | 06 | 0.023 |
| No Diabetes | 77 | 06 | 57 | 14 | |
| Correlation with smoking | |||||
| Smoking | 63 | 05 | 45 | 13 | <0.667 |
| No Smoking | 37 | 05 | 25 | 07 | |
| Correlation with alcohol consumption | |||||
| Alcohol | 40 | 04 | 24 | 16 | <0.001 |
| No Alcohol | 60 | 06 | 46 | 04 | |
| Correlation with Pan Masala consumption | |||||
| Pan Masala | 02 | 1 | 1 | 0 | <0.206 |
| No Pan Masala | 98 | 09 | 69 | 20 | |