Table 6.

Association of COMT rs4680 G/A gene variation with coronary artery disease.

Genotype	Healthy Controls		CAD Patients		OR (95% CI)	Risk Ratio (RR)	p-Value
	(N = 100)	%	(N = 100)	%
Codominant inheritance model
COMT-GG	30	30%	10	10%	1 (ref.)	1 (ref.)
COMT-GA	60	60%	70	70%	3.5 (1.58–7.74)	1.62 (1.25–2.10)	0.002
COMT-AA	10	10%	20	20%	6.0 (2.11–17.03)	2.25 (1.31–3.8)	<0.003
Dominant inheritance model
COMT-GG	30	30%	10	10%	1 (ref.)	1 (ref.)
COMT-(GA + AA)	70	70%	90	90%	3.85 (1.76–8.4)	1.71 (1.33–2.20)	<0.0007
Recessive inheritance model
COMT-(GG + GA)	90	90%	80	81.63%	1 (ref.)	1 (ref.)
COMT-AA	10	10%	18	18.36%	2.02 (0.86–4.7)	1.05 (0.74–1.51)	0.72
Allele
COMT-G	120	60%	90	45.45%	1 (ref.)	1 (ref.)
COMT-A	80	40%	108	54.55%	1.8 (1.20–2.67)	1.34 (1.09–1.64)	<0.004