Table 1.
Circulating inflammatory proteins statistically significantly associated with tumor EBV positivity.
| Protein (Other Names) | Marker Level Tertile | Age- and Sex-Adjusted OR (95% CI) |
|---|---|---|
| CCL20 (MIP-3A) | 1 | 1.0 |
| 2 | 2.33 (0.57–9.49) | |
| 3 | 12.30 (2.68–56.36) | |
| p-trend | 0.001 | |
| AUC | 0.76 | |
| CXCL9 (MIG, EBV-induced molecule 1 ligand chemokine) | 1 | 1.0 |
| 2 | 2.17 (0.44–10.81) | |
| 3 | 11.49 (2.08–63.55) | |
| p-trend | 0.003 | |
| AUC | 0.74 | |
| PD-L1 (CD274) | 1 | 1.0 |
| 2 | 5.80 (0.96–35.18) | |
| 3 | 13.73 (2.21–85.07) | |
| p-trend | 0.004 | |
| AUC | 0.73 | |
| IL-10 | 1 | 1.0 |
| 2 | 2.91 (0.73–11.61) | |
| 3 | 5.72 (1.33–24.65) | |
| p-trend | 0.019 | |
| AUC | 0.67 | |
| CCL19 (MIP-3B) | 1 | 1.0 |
| 2 | 1.12 (0.30–4.20) | |
| 3 | 5.03 (1.30–19.49) | |
| p-trend | 0.019 | |
| AUC | 0.67 | |
| CCL11 (Eotaxin-1) | 1 | 1.0 |
| 2 | 1.57 (0.41–6.09) | |
| 3 | 4.74 (1.18–19.02) | |
| p-trend | 0.026 | |
| AUC | 0.70 | |
| IL-17A | 1 | 1.0 |
| 2 | 4.29 (1.11–16.64) | |
| 3 | 4.28 (1.09–16.80) | |
| p-trend | 0.038 | |
| AUC | 0.67 | |
| CCL8 (MCP-2) | 1 | 1.0 |
| 2 | 2.10 (0.56–7.88) | |
| 3 | 3.72 (1.01–13.75) | |
| p-trend | 0.049 | |
| AUC | 0.67 |
Abbreviations: OR, odds ratio; CI, confidence interval; AUC, area under the receiver operating characteristic curve.