Table 3.
Tuberculosis Infection/Metformin Exposure | n | N | HR | 95% CI | p Value |
---|---|---|---|---|---|
Any tuberculosis infection | |||||
Never users | 360 | 15,799 | 1.000 | ||
Ever users | 496 | 50,195 | 0.438 | (0.382–0.501) | <0.0001 |
Tertiles of cumulative duration of metformin therapy (months) | |||||
Never users | 360 | 15,799 | 1.000 | ||
<27.10 | 217 | 16,349 | 0.889 | (0.748–1.055) | 0.1781 |
27.10–58.27 | 167 | 13,683 | 0.523 | (0.435–0.628) | <0.0001 |
>58.27 | 112 | 20,163 | 0.190 | (0.153–0.235) | <0.0001 |
Tertiles of cumulative dose of metformin therapy (mg) | |||||
Never users | 360 | 15,799 | 1.000 | ||
<817,000 | 218 | 16,919 | 0.847 | (0.713–1.005) | 0.0572 |
817,000–2,047,180 | 151 | 14,180 | 0.443 | (0.366–0.535) | <0.0001 |
>2,047,180 | 127 | 19,096 | 0.230 | (0.188–0.282) | <0.0001 |
Pulmonary tuberculosis infection | |||||
Never users | 324 | 15,799 | 1.000 | ||
Ever users | 439 | 50,195 | 0.431 | (0.373–0.497) | <0.0001 |
Tertiles of cumulative duration of metformin therapy (months) | |||||
Never users | 324 | 15,799 | 1.000 | ||
<27.10 | 190 | 16,349 | 0.852 | (0.710–1.023) | 0.0853 |
27.10–58.27 | 149 | 13,683 | 0.517 | (0.426–0.629) | <0.0001 |
>58.27 | 100 | 20,163 | 0.189 | (0.151–0.237) | <0.0001 |
Tertiles of cumulative dose of metformin therapy (mg) | |||||
Never users | 324 | 15,799 | 1.000 | ||
<817,000 | 191 | 16,919 | 0.813 | (0.678–0.976) | 0.0262 |
817,000–2,047,180 | 135 | 14,180 | 0.440 | (0.360–0.537) | <0.0001 |
>2,047,180 | 113 | 19,096 | 0.228 | (0.184–0.283) | <0.0001 |
n: incident case number of tuberculosis infection, N: case number followed. HR: hazard ratio (propensity score weighted), CI: confidence interval.