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. 2018 Oct;16(10):1598–1606.e4. doi: 10.1016/j.cgh.2018.03.007

Figure 1.

Figure 1

Regional association plots for genotyped single nucleotide polymorphisms (SNPs) showing P values for interaction for (A) smoking status and (B) recurrent gastroesophageal reflux disease symptoms in esophageal adenocarcinoma and (C) body mass index and (D) pack-years of smoking exposure in Barrett’s esophagus. The SNPs in Table 2 are shown as a solid purple diamond, except in panel B where rs2341926 and rs13396805 are shown as circles near rs12465911. The color scheme indicates linkage disequilibrium between the SNP shown with a solid purple diamond and other SNPs in the region using the r2 value calculated from the 1000 Genomes Project. The y axis is the −log10 interaction P value computed from 5388 cases (3104 Barrett’s esophagus, 2284 esophageal adenocarcinoma) and 2182 control subjects. The recombination rate from CEU HapMap data (right-side y axis) is shown in light blue. (A) Chromosome 2p25.1; (B) chromosome 2q23.3 region; (C) chromosome 1p34.3 region; (D) chromosome 15q14 region.