Table 2.
Gene-Environment Interactions With EA or BE With a P Value for Interaction <5.0 × 10–7
| Outcome | Exposure | SNP | Chr | Position | Gene | Effect/ Other |
EAF | OR | P |
|---|---|---|---|---|---|---|---|---|---|
| EA | |||||||||
| Smoking status | rs13429103 | 2p25.1 | 7517231 | RNF144A-LOC339788 | A/G | 0.15 | 2.04 | 2.18 × 10–7 | |
| Recurrent GERD symptoms | rs12465911 | 2q23.3 | 151785742 | RND3-RBM43 | A/G | 0.26 | 2.03 | 1.70 × 10–7 | |
| Recurrent GERD symptoms | rs2341926 | 2q23.3 | 151783928 | RND3-RBM43 | C/T | 0.26 | 2.02 | 1.83 × 10–7 | |
| Recurrent GERD symptoms | rs13396805 | 2q23.3 | 151821512 | RND3-RBM43 | A/G | 0.26 | 1.99 | 3.58 × 10–7 | |
| BE | |||||||||
| BMI (continuous) | rs491603 | 1p34.3 | 36532316 | EIF2C3-LOC100128093 | A/G | 0.16 | 1.08 | 4.44 × 10–7 | |
| Pack-years of smoking | rs11631094 | 15q14 | 34624438 | SLC12A6 | A/C | 0.29 | 0.99 | 2.82 × 10–7 |
BE, Barrett’s esophagus; BMI, body mass index; EA, esophageal adenocarcinoma; EAF, effect allele frequency; GERD, gastroesophageal reflux disease; OR, odds ratio; SNP, single nucleotide polymorphism.