Table 3.
Risk of EA and BE in Association With Obesity, Smoking History and Recurrent GERD Symptoms, Stratified by Genotype for SNPs in Table 2
| Outcome | Environmental Exposure | SNP | Genotype | Cases/Control Subjects | OR | 95% CI | P Valuea |
|---|---|---|---|---|---|---|---|
| EA | |||||||
| Ever smoker vs never smoker (ref) | rs13429103 | GG | 1617/1572 | 1.59 | 1.36–1.85 | <.001 | |
| GA | 589/554 | 2.91 | 2.23–3.81 | <.001 | |||
| AA | 48/44 | 11.82 | 4.03–34.67 | <.001 | |||
| Recurrent GERD symptoms vs nonrecurrent GERD symptoms (ref) | rs12465911 | GG | 1206/1196 | 2.80 | 2.29–3.41 | <.001 | |
| GA | 885/823 | 5.32 | 4.10–6.90 | <.001 | |||
| AA | 163/151 | 13.12 | 6.21–27.73 | <.001 | |||
| Recurrent GERD symptoms vs nonrecurrent GERD symptoms (ref) | rs2341926 | TT | 975/985 | 2.80 | 2.30–3.42 | <.001 | |
| TC | 724/681 | 5.30 | 4.08–6.88 | <.001 | |||
| CC | 120/128 | 13.12 | 6.21–27.73 | <.001 | |||
| Recurrent GERD symptoms vs nonrecurrent GERD symptoms (ref) | rs13396805 | GG | 998/1005 | 2.85 | 2.34–3.48 | <.001 | |
| GA | 701/662 | 5.23 | 4.02–6.81 | <.001 | |||
| AA | 120/127 | 12.73 | 6.12–26.49 | <.001 | |||
| BE | |||||||
| BMI ≥30 kg/m2 vs BMI <25 kg/m2 (ref) | rs491603 | GG | 1306/1137 | 1.52 | 1.38–1.67 | <.001 | |
| GA | 438/518 | 2.11 | 1.80–2.47 | <.001 | |||
| AA | 42/64 | 3.30 | 1.90–5.73 | <.001 | |||
| ≥15 pack-years vs <15 pack-years (ref) | rs11631094 | CC | 729/618 | 1.02 | 0.81–1.30 | .846 | |
| CA | 555/540 | 0.65 | 0.50–0.84 | .001 | |||
| AA | 115/106 | 0.52 | 0.28–0.95 | .033 |
BE, Barrett’s esophagus; BMI, body mass index; CI, confidence interval; EA, esophageal adenocarcinoma; GERD, gastroesophageal reflux disease; OR, odds ratio; SNP, single nucleotide polymorphism.
a
P values from logistic regression analysis adjusted for age and sex.