Supplemental Table 1.
Gene-Environment Interactions With EA or BE With a P Value for Interaction <1.0 × 10–6
| Outcome | Exposure | SNP | Chr | Position | Gene | Effect/ Other |
EAF | OR | P Value |
|---|---|---|---|---|---|---|---|---|---|
| EA | |||||||||
| Smoking status | rs2434584 | 5q11.2 | 57566073 | ACTBL2-PLK2 | C/T | 0.08 | 2.52 | 7.44 × 10–7 | |
| Smoking status | rs40210 | 5q11.2 | 57619964 | ACTBL2-PLK2 | A/G | 0.08 | 2.46 | 8.82 × 10–7 | |
| Pack-years of smoking | rs17002540 | Xq27.1 | 139946061 | CDR1-SPANXB2 | T/C | 0.19 | 0.99 | 5.92 × 10–7 | |
| Recurrent GERD symptoms | rs2971030 | 7p21.3 | 10006341 | LOC340268 | G/A | 0.42 | 1.77 | 6.02 × 10–7 | |
| Recurrent GERD symptoms | rs7141987 | 14q32.31 | 101492224 | SNORD114-31-LOC100130814 | G/A | 0.42 | 1.77 | 7.11 × 10–7 | |
| Recurrent GERD symptoms | rs2971028 | 7p21.3 | 10007255 | LOC340268 | A/G | 0.40 | 1.76 | 8.56 × 10–7 | |
| BE | |||||||||
| Pack-years of smoking | rs9668109 | 12q23.1 | 99011272 | IKIP | A/G | 0.09 | 0.98 | 6.31 × 10–7 | |
| Pack-years of smoking | rs1548445 | 16p12.3 | 19691583 | C16orf62 | G/A | 0.06 | 1.02 | 8.21 × 10–7 | |
| Pack-years of smoking | rs2671828 | 17q12 | 33731764 | SLFN11-LOC729839 | A/G | 0.43 | 0.99 | 9.54 × 10–7 | |
| Pack-years of smoking | rs10507102 | 12q23.1 | 98990871 | SLC25A3 | A/G | 0.09 | 0.98 | 9.91 × 10–7 |
BE, Barrett’s esophagus; BMI, body mass index; EA, esophageal adenocarcinoma; EAF, effect allele frequency; GERD, gastroesophageal reflux disease; OR, odds ratio; SNP, single nucleotide polymorphism.