Supplemental Table 2.

Risk of EA and BE in Association With Smoking History and GERD Symptoms, Stratified by Genotype for SNPs in Supplemental Table 1

Outcome	Environmental Exposure	SNP	Genotype	Cases/Control Subjects	OR	95% CI	P Valuea
EA
	Ever smoker vs never smoker (ref)	rs2434584	TT	1907/1826	1.67	1.45–1.93	<.001
			CT	342/328	4.33	3.00–6.24	<.001
			CC	5/15	NA	-	-
	Ever smoker vs never smoker (ref)	rs40210	GG	1903/1821	1.67	1.45–1.92	<.001
			GA	344/332	4.24	2.96–6.06	<.001
			AA	6/16	NA	-	-
	≥15 pack-years vs <15 pack-years (ref)	rs17002540	CC	1053/1003	1.36	1.12–1.66	.002
			CT	48/55	0.78	0.33–1.86	.579
			TT	218/206	0.63	0.39–1.00	.052
	Recurrent GERD symptoms vs nonrecurrent GERD symptoms (ref)	rs2971030	AA	599/603	2.68	2.08–3.44	<.001
			GA	908/895	3.81	3.06–4.75	<.001
			GG	309/293	9.44	6.17–14.45	<.001
	Recurrent GERD symptoms vs nonrecurrent GERD symptoms (ref)	rs7141987	AA	591/590	2.69	2.08–3.49	<.001
			GA	908/887	3.74	3.02–4.64	<.001
			GG	319/317	9.32	6.04–14.36	<.001
	Recurrent GERD symptoms vs nonrecurrent GERD symptoms (ref)	rs2971028	GG	625/635	2.70	2.11–3.45	<.001
			GA	900/890	3.87	3.10–4.82	<.001
			AA	294/268	9.58	6.17–14.88	<.001
BE
	≥15 pack-years vs <15 pack-years (ref)	rs9668109	GG	1167/1058	0.92	0.77–1.11	.390
			GA	221/201	0.38	0.25–0.60	<.001
			AA	11/5	0.33	0.02–5.64	.443
	≥15 pack-years vs <15 pack-years (ref)	rs1548445	AA	1223/1097	0.76	0.63–0.91	.002
			GA	170/164	1.11	0.68–1.80	.675
			GG	6/3	NA	-	-
	≥15 pack-years vs <15 pack-years (ref)	rs2671828	GG	457/423	0.93	0.70–1.23	.595
			GA	688/588	0.84	0.66–1.07	.163
			AA	246/250	0.54	0.36–0.80	.002
	≥15 pack-years vs <15 pack-years (ref)	rs10507102	GG	1166/1058	0.93	0.77–1.11	.409
			GA	222/200	0.38	0.24–0.59	<.001
			AA	11/5	0.33	0.02–5.64	.443

BE, Barrett’s esophagus; BMI, body mass index; EA, esophageal adenocarcinoma; EAF, effect allele frequency; GERD, gastroesophageal reflux disease; SNP, single nucleotide polymorphism.

^aP values from logistic regression analysis adjusted for age and sex.