Supplemental Table 3.
Comparison of Gene-Environment Interactions in BE and EA for SNPs With P Value for Interaction <1.0 × 10–6 on the Outcomes
| Exposure | SNP | Chr | Position | Gene | Effect/ Other |
BE |
EA |
||
|---|---|---|---|---|---|---|---|---|---|
| OR | P | OR | P | ||||||
| G × E hits for EA | |||||||||
| Smoking status | rs13429103 | 2p25.1 | 7517231 | RNF144A-LOC339788 | A/G | 1.40 | 3.51 × 10–3 | 2.04 | 2.18 × 10–7 |
| Smoking status | rs2434584 | 5q11.2 | 57566073 | ACTBL2-PLK2 | C/T | 1.56 | 3.90 × 10–3 | 2.52 | 7.44 × 10–7 |
| Smoking status | rs40210 | 5q11.2 | 57619964 | ACTBL2-PLK2 | A/G | 1.54 | 4.94 × 10–3 | 2.46 | 8.82 × 10–7 |
| Pack-years of smoking | rs17002540 | Xq27.1 | 139946061 | CDR1-SPANXB2 | T/C | 0.99 | 4.83 × 10–3 | 0.99 | 5.92 × 10–7 |
| Recurrent GERD symptoms | rs12465911 | 2q23.3 | 151785742 | RND3-RBM43 | A/G | 1.66 | 6.09 × 10–5 | 2.03 | 1.70 × 10–7 |
| Recurrent GERD symptoms | rs2341926 | 2q23.3 | 151783928 | RND3-RBM43 | C/T | 1.65 | 7.38 × 10–5 | 2.02 | 1.83 × 10–7 |
| Recurrent GERD symptoms | rs13396805 | 2q23.3 | 151821512 | RND3-RBM43 | A/G | 1.59 | 2.80 × 10–4 | 1.99 | 3.58 × 10–7 |
| Recurrent GERD symptoms | rs2971030 | 7p21.3 | 10006341 | LOC340268 | G/A | 1.36 | 5.03 × 10–3 | 1.77 | 6.02 × 10–7 |
| Recurrent GERD symptoms | rs7141987 | 14q32.31 | 101492224 | SNORD114-31-LOC100130814 | G/A | 1.29 | 1.40 × 10–2 | 1.77 | 7.11 × 10–7 |
| Recurrent GERD symptoms | rs2971028 | 7p21.3 | 10007255 | LOC340268 | A/G | 1.35 | 6.10 × 10–3 | 1.76 | 8.56 × 10–7 |
| G × E hits for BE | |||||||||
| BMI (continuous) | rs491603 | 1p34.3 | 36532316 | EIF2C3-LOC100128093 | A/G | 1.08 | 4.44 × 10–7 | 1.04 | 1.83 × 10–2 |
| Pack-years of smoking | rs11631094 | 15q14 | 34624438 | SLC12A6 | A/C | 0.99 | 2.82 × 10–7 | 1.00 | 0.125 |
| Pack-years of smoking | rs9668109 | 12q23.1 | 99011272 | IKIP | A/G | 0.98 | 6.31 × 10–7 | 0.99 | 9.74 × 10–3 |
| Pack-years of smoking | rs1548445 | 16p12.3 | 19691583 | C16orf62 | G/A | 1.02 | 8.21 × 10–7 | 1.01 | 9.70 × 10–2 |
| Pack-years of smoking | rs2671828 | 17q12 | 33731764 | SLFN11-LOC729839 | A/G | 0.99 | 9.54 × 10–7 | 1.00 | 6.13 × 10–2 |
| Pack-years of smoking | rs10507102 | 12q23.1 | 98990871 | SLC25A3 | A/G | 0.98 | 9.91 × 10–7 | 0.99 | 6.93 × 10–3 |
BE, Barrett’s esophagus; BMI, body mass index; EA, esophageal adenocarcinoma; EAF, effect allele frequency; G × E, gene-environment; GERD, gastroesophageal reflux disease; OR, odds ratio; SNP, single nucleotide polymorphism.