Supplemental Table 4.

Associations of Previously Reported Gene-Environment Interactions With Esophageal Adenocarcinoma in Our Study Population

Original Publication				Current Study
Author	SNP	Exposure	P Value	Directly Genotyped or High-LD SNP	P Value
Casson et al, 200624	NA	-	-	-	-
Zhai et al, 200825	rs833061	Smoking	.03	rs833070	.068
Doecke et al, 200826	rs12269324	GERD symptoms	-	Direct	.979
	rs12268840	GERD symptoms	-	Direct	.714
Cheung et al, 200927	rs4444903	GERD symptoms	<.001a	Direct	.240
Zhai et al, 201228	rs1143634	GERD symptoms	.008	Direct	.398
	rs1052486	BMI + Smoking	-	-	-
	rs1052486	BMI	-	Direct	.423
	rs1052486	Smoking	-	Direct	.532
Wu et al, 201129	rs648802	GERD symptoms	.02	Direct	.838
	rs4855094	GERD symptoms	.04	Direct	.872
	rs7644468	GERD symptoms	.04	-	-
	rs4149579	GERD symptoms	.04	-	-
	rs560191	Smoking	.02	Direct	.331
	rs7907519	Smoking	.04	rs11196449	.868
	rs12454712	Smoking	.04	Direct	.435
Zhai et al, 201230	rs2295778	GERD symptoms	.0005	rs12780796	.654
	rs13337626	GERD symptoms	.0067	rs34197769	.315
	rs2295778	Smoking	.004	-	-
	rs2296188	Smoking	.014	Direct	.905
	rs2114039	BMI	.0026	Direct	.228
	rs2296188	BMI	.0023	Direct	.452
	rs11941492	BMI	.013	Direct	NAb
	rs17708574	BMI	.013	Direct	.316
	rs7324547	BMI	.008	-	-
	rs17619601	BMI	.016	-	-
	rs17625898	BMI	.023	-	-
Cheung et al, 201231	rs1799750	GERD symptoms	.002	-	-
	rs3025058	GERD symptoms	.04	-	-

BMI, body mass index; GERD, gastroesophageal reflux disease; LD, linkage disequilibrium; SNP, single nucleotide polymorphism.

^aTwo-way interaction.

^bOn array but quality control failure. We were unable to validate all SNPs as some were biallelic or we failed to identify a high LD SNP (r² < 0.70).