Table 2.

Overview of blood samples obtained at all visits

Clinical chemistry	Hemoglobin, white blood cells, differential white cell count, platelets, creatinine, urea, bilirubin, potassium, sodium, chloride, total calcium, phosphate, magnesium, CRP, albumin, triglycerides, vitamin-D
Inflammatory biomarkers	High-sensitivity CRP, IL-1β, IL-1, IL-1ra, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8/CXCL-8, IL-9, IL-10, IL-12 (p70), IL-13, IL-15, IL-17, basic fibroblast growth factor (bFGF), granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon-gamma (IFN-ɣ), eotaxin/CCL11, IFN-ɣ-inducible protein (IP-10)/CXCL10, MCP-1)/CCL2, MIP-1α/CCL3), MIP-1β/CCL4, regulated on activation, normal T-cell expressed and secreted (RANTES)/CCL5, TNF, platelet-derived growth factor (PDGF), and vascular endothelial growth factor (VEGF).
Biomarkers involved in bone remodelling	RANK-ligand (RANKL), Osteoprotegerin (OPG) and Notch Ligands: DLL1 and Periostin.