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. 2018 Sep 21;24:6656–6665. doi: 10.12659/MSM.909093

Figure 1.

Figure 1

Let-7c-5p attenuated LPS-induced inflammation and increased cell viability in DPSCs. DPSCs were infected with NC lentivirus particles and let-7c-5p expression lentivirus particles. At 72 h after infection, the cells were incubated with 10 μg/ml LPS for 24 h to induce inflammatory response. Upon completion of the inflammation induction, the cells were collected and subjected to ELISA for detection of IL-1β and TNF-α production and MTT assay for detection of cell viability. Administration of LPS suppressed the expression of let-7c-5p and infection of let-7c-5p expression vector increased the expression of let-7c-5p (A). The induced expression of let-7c-5p inhibited the production of IL-1β (B) and TNF-α (C) and increased the cell viability of DPSCs due to LPS administration (D). * P<0.05 vs. Blank group. # P<0.05 vs. LPS or LPS+NC group. Each assay was represented by 3 replicates.