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. 2018 Sep 25;10:3881–3890. doi: 10.2147/CMAR.S174778

Figure 2.

Figure 2

Knockdown of circZNF609 inhibits breast cancer cell proliferation, migration, and invasion in vitro.

Notes: (A) qRT-PCR analysis of the interfering efficacies of three circZNF609-targeting siRNAs on circZNF609 and ZNF609 in MCF7 and MDA-MB-231 cell lines. (B) CCK-8 assay of MCF7 and MDA-MB-231 cells transfected with si-circZNF609#1 or NC. (C) EdU assay of MCF7 and MDA-MB-231 cells transfected with si-circZNF609#1 or NC. Scale bar=20 µm. (D) Transwell migration and Matrigel invasion assay of MCF7 and MDA-MB-231 cells transfected with si-circZNF609#1 or NC. Scale bar=20 µm. Data were represented as mean±SD of at least three independent experiments. *P<0.05, **P<0.01, ***P<0.001.

Abbreviations: EdU, ethynyldeoxyuridine; NC, negative control; qRT-PCR, quantitative reverse transcription-PCR; CCK-8, cell-counting kit-8.