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. 2018 Sep 21;9:321–328. doi: 10.2147/PROM.S144425

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© 2018 Graney and Lee. This work is published and licensed by Dove Medical Press Limited

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Positive and negative influences on HRQL in IPF.

Notes: Symptoms, and dyspnea in particular, are the most influential drivers of impaired HRQL in IPF. Other drivers of impaired HRQL include the resultant physical functional limitations due to deconditioning, mood disorders and comorbidities, and the constraints of supplemental oxygen. Pulmonary rehabilitation is associated with improved HRQL in IPF. Pharmacologic therapies, management of comorbid conditions, and a multidisciplinary approach to diagnosis and management may also improve HRQL for some patients.

Abbreviations: HRQL, health-related quality of life; IPF, idiopathic pulmonary fibrosis.