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PI3K is the main signaling pathway downstream PDGFRα in PrE development. (A) Two E3.5 Fgfr1−/−; PdgfraPI3K/PI3K embryos are shown. NANOG (green) labels Epi cells, GATA4 (red) labels PrE. DAPI (blue) used to counter label cell nuclei. (B) Number of PrE cells in Fgfr1−/−; PdgfraPI3K/PI3K embryos (red box) are shown compared to Fgfr1 & Pdgfra compound mutants. Scale bars, 50 μm.
