Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model for FGF and PDGF signaling in PrE development. At the mid-blastocyst stage, FGF4 is produced by a subpopulation of the ICM cells and signals in a paracrine fashion through ERK1/2 to induce PrE cells. In expanded blastocysts, PDGFA signaling to PDGFRα, and potentially FGF4 signaling to FGFR2, activates PI3K in newly forming PrE cells, which controls their survival.
