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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: J Pain. 2018 Apr 30;19(10):1147–1156. doi: 10.1016/j.jpain.2018.04.006

Figure 3. Lipid peroxidation levels increased in skin, muscle and sciatic nerve after fracture/cast and Vit C or NAC treatment reversed this up regulation.

Figure 3.

Elevated concentrations of the lipid peroxidation product malondialdehyde (MDA) were detected in the ipsilateral (A) hindpaw skin, (B) gastrocnemius muscle, and (C) sciatic nerve at 4 weeks after tibia fracture/cast. Four weeks treatment with Vit C inhibited the post-fracture/cast increase in MDA levels in skin, muscle and sciatic nerve. Intraperitoneal injection of the antioxidant NAC at 4 weeks post fracture also inhibited the increase in MDA in skin and sciatic nerve. Data are expressed as mean values ± SEM and analyzed using one-way ANOVA followed by post hoc Newman-Keuls multiple comparison testing (n=7 per cohort). *P < 0.05, **P < 0.01 and ***P < 0.001 vs. nonfracture Controls treated with vehicle; #P < 0.05, ##P < 0.01 and ###P < 0.001 vs. FX/Cast treated with vehicle.