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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: J Pain. 2018 Apr 30;19(10):1147–1156. doi: 10.1016/j.jpain.2018.04.006

Figure 5. Sciatic nerve SP and CGRP levels increased after fracture/cast and Vit C treatment inhibited this increase.

Figure 5.

At 4 weeks after fracture/cast both SP (A) as well as CGRP (B) protein levels were increased in the ipsilateral sciatic nerve and a 4 week course of Vit C treatment (200 mg/kg/day p.o.) inhibited this increase. Data are expressed as mean values ± SEM and analyzed using one-way ANOVA followed by post hoc Newman-Keuls multiple comparison testing (n=7 per cohort). *P<0.05 and **P < 0.01 vs. nonfracture Controls treated with vehicle; #P < 0.05 vs. FX/Cast treated with vehicle.