Table 7:
Pharmacokinetic parameters (mean ± SD) of CLBQ14 following the administration of 2, 5 and 10 mg/kg single IV bolus doses.
| Pharmacokinetic Parameter (Unit) | 2 mg/kg (n = 4) | 5 mg/kg (n = 3) | 10 mg/kg (n = 4) |
|---|---|---|---|
| C0(mg/L) | 1.44 ± 0.27 | 3.24 ± 0.44 | 5.27 ± 1.43 |
| AUC0−∞(hr*mg/L) | 1.36 ± 0.06 | 1.96 ± 0.40 | 4.83 ± 0.74 |
| A (mg/L) | 1.39 ± 0.27 | 3.14 ± 0.42 | 5.09 ± 1.36 |
| T1/2α(hr) | 0.16 ± 0.04 | 0.17 ± 0.03 | 0.25 ± 0.09 |
| B (mg/L) | 0.05 ± 0.00 | 0.09 ± 0.04 | 0.17 ± 0.07 |
| T1/2β(hr) | 14.8 ± 0.53 | 10.0 ± 4.60 | 13.4 ± 3.59 |
| Vss(L/kg) | 24.3 ± 1.28 | 23.2 ± 11.5 | 27.3 ± 11.6 |
| Cl (L/hr/kg) | 1.48 ± 0.07 | 2.62 ± 0.50 | 2.11 ± 0.32 |
C0 = concentration at time zero; AUC0−∞ = area under curve from time zero to infinity;
A = coefficient of distributional phase; T1/2α = half-life of distributional phase;
B = coefficient of terminal phase; T1/2β = elimination half-life of the beta elimination phase;
Vss = volume of distribution at steady state; Cl = total clearance