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. Author manuscript; available in PMC: 2019 Mar 12.
Published in final edited form as: Nature. 2018 Sep 12;561(7724):547–550. doi: 10.1038/s41586-018-0515-2

Extended Data Figure 1. Effects on tactile behaviors and gross locomotion in mice with pyramidotomy.

Extended Data Figure 1

a, Correlation between CST ablation and tactile behaviors in mice with pyramidotomy. For individual animals, tag number, image and quantification of L3 spinal cord sections stained with anti- PKCγ antibody showing remaining CST axons, percentage of withdrawal response to low-threshold von Frey (0.16g) and light brush, and sense time to the tape were present in the group receiving pyramidotomy. b-c, Performance on over ground walking (b, P=0.14, hindlimb weight support; P=0.81, hindlimb retraction; P=0.41, hindlimb protraction; P=0.81, inter-limb coordination; P=0.20, fore-hindlimb coordination), and rotarod test (c, P=0.87) in mice with sham (n=8) or pyramidotomy (n=12). n.s.: no statistical significance. Two-sided student’s t-test. Data are presented as mean ± SEM.