Table I.

Thermodynamic Parameters for Association of Ag⁺ with Nucleotides and Nucleosides^a

Ligand	ΔH (kcal/mole)	N (Ag+:Ligand)	K (M−1)	ΔG (kcal/mole)	ΔS (cal/(mole K))
5’-guanosine monophosphate	−9.8 ± 0.5	2.3 ± 0.1	9.6 (± 1.9) × 104	−6.8 ± 0.1	−10 ± 2
5’-cytosine monophosphate	−3.0 ± 0.8	1.1 ± 0.3	1.3 (± 0.3) × 103	−4.3 ± 0.1	−4 ± 3
guanosine	−14.7 ± 1.0	1.33 ± 0.05	1.8 (± 0.2) × 105	−7.2 ± 0.1	−25 ± 3
5’-guanosine monophosphate in 1 M NaClO4	−12.1 ± 0.8	1.5 ± 0.1	6.6 (± 1.2) × 104	−6.6 ± 0.1	−19 ± 3
5’-guanosine monophosphate in 100 mM LiClO4	−11.0 ± 1.0	2.1 ± 0.2	6.0 (± 0.6) × 104	−6.5 ± 0.1	−15 ± 3
7-deazaguanosine	−1.4± 0.3	1.15 ± 0.25	1.6 (± 0.7) × 104	−5.7 ± 0.3	14 ± 1
5’-inosine monophosphate	−9.7 ± 0.2	2.3 ± 0.1	9.2 (± 0.2) × 104	−6.8 ± 0.1	−10. ± 1

^aNucleotide and nucleoside concentrations were 100 μM