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. 2018 Sep 5;16(9):314. doi: 10.3390/md16090314

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Microsclerodermin D (16) biosynthesis in Jahnella sp. A = adenylation, ACL = acyl-CoA ligase, ACP = acyl carrier protein, AH = amidohydrolase (putative), AMT = aminotransferase, AT = acyltransferase, C = condensation domain, DH = dehydratase, E = epimerase, HAL = tryptophan halogenase, KR = ketoreductase, KS = ketosynthases, MOX = monooxygenase, NMT = N-methyltransferase, PCP = peptidyl carrier protein, and TE = thioesterase. Modules are noted by letter and number as given by m1 for module 1. Curved lines in MscH and MscI denote domains that are covalently attached and are shown separately for ease in depicting the pendant NRPS/PKS chain. AT, ACP, KS, DH, ER, KR, and TE are enzymes commonly observed in PKSs. C, A, PCP, NMT, E and TE are enzymes commonly observed in NRPSs. HAL is a tailoring enzyme. The structural assignment of the microsclerodermins has been a subject of revision [67]. The structure presented for 16 is based on all isolation and chemical synthetic data presented to date.